Between Two COO's with Michael Koenig

Michael Koenig

Between Two COOs is hosted by veteran COO Michael Koenig and brings together Chief Operating Officers, executives, and business leaders to share real insights on operations, leadership, scaling, AI, and execution. Featuring COOs from companies like LVMH, Vodafone, Automattic, Lime, JumpCloud, Grafana Labs, and Cotopaxi, plus top VCs like Brad Feld and Seth Levine. Whether you're a COO, VP of Ops, founder, or aspiring operator — this is the podcast for people who actually run companies. New episodes weekly. betweentwocoos.com | b2coos.com

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Between Two COO's with Michael Koenig

Episodes (70)

Sep 30th Tom Masterson, Deep Genomics COO on AI Drug Discovery That Learned the Rules
Sep 22nd The AI Bubble Has a Due Date. It's 2029 | Paul Kedrosky, SK Ventures
Sep 16th Lior Eldan, Moburst COO on Reinventing the Marketing Agency Before AI Eats It

Between Two COO's with Michael Koenig

Sep 30, 2026
48¾ minutes
43 MB

Tom Masterson, COO of Deep Genomics, on AI drug discovery where precision beats creativity. He explains how the company's siRNA model picked an approved cholesterol drug out of 3,500 candidates for a target it had never seen, why it designs toxic molecules on purpose, and how a COO runs a company where the lab and the software move on different clocks. In this episode, Tom and Michael discuss: The difference between life sciences and healthcare, and where a tech bio company fitsBrendan Frey, Geoffrey Hinton's lab, and a thesis that was right but earlyRetiring 40 task-specific models when...

Between Two COO's with Michael Koenig

Tom Masterson, Deep Genomics COO on AI Drug Discovery That Learned the Rules

Michael Koenig

00:00 -46:57