Fireside Chats on Endocrinology and Metabolism in the Mantzoros lab

The Mantzoros Lab

This podcast is hosted by Prof. Christos Mantzoros, MD, DSc, PhD hc mult, assisted by his team member Dr. Laura Valenzuela, at the Mantzoros Lab at Harvard Medical School / BIDMC. We want to utilize this platform to provide a novel way to share clinically relevant and scientifically novel information about cutting-edge concepts in the fields of Endocrinology, Diabetes, Nutrition, and Metabolism. Let's share the passion for the endocrine system, mentorship, and innovation! ---------------------------------- The following music was used for this media project: Music: Total Happy Up And Sunny by Sascha Ende. License (CC BY 4.0): https://filmmusic.io/standard-license. Artist website...

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Fireside Chats on Endocrinology and Metabolism in the Mantzoros lab

Episodes (10)

Nov 24, 2025 The Hidden Cost of Weight Loss Meds: Reevaluating Muscle, Metabolism, and Modern Obesity Treatments
Jan 22, 2024 Emerging Pharmacotherapies and Future Perspectives for Obesity Treatment
Oct 24, 2023 ESPAÑOL: De Hígado Graso No Alcohólico (NAFLD) a Enfermedad Hepática Esteatósica Asociada a Disfunción Metabólica (MASLD)

Fireside Chats on Endocrinology and Metabolism in the Mantzoros lab

Nov 24, 2025
12 minutes
14 MB

Current and emergent incretin-based therapies (such as GLP-1 and GIP receptor agonists) have transformed obesity treatment by producing unprecedented weight loss. But these benefits come with complexity: significant lean mass loss, raising concerns about metabolic stability, muscle health, and long-term outcomes. In this episode, we briefly revisit the clinical approach to weight-loss medications, connect the foundations of leptin dysregulation with leptin-independent pathways (including the activin/follistatin/myostatin/IGF-1 system), and link these pathways to energy homeostasis and muscle maintenance. We also discuss strategies to preserve lean mass during significant pharmacologically-induced weight reduction.

Fireside Chats on Endocrinology and Metabolism in the Mantzoros lab

The Hidden Cost of Weight Loss Meds: Reevaluating Muscle, Metabolism, and Modern Obesity Treatments

The Mantzoros Lab

00:00 -11:46